Professor Hala Zreiqat

Bioactive Ceramics and Architected BRedefining musculoskeletal regeneration: Innovations and vision for the future of biomedical engineering

Abstract

Musculoskeletal diseases and injuries remain a major global health challenge, particularly among ageing populations where impaired repair of musculoskeletal tissues, including bone and cartilage, continues to limit recovery and quality of life. Our research focuses on developing next-generation biomaterials that integrate advanced chemistry, nano-architecture, and cellular biology to address these challenges. The presentation will highlight our recent work on bioactive ceramics and nanostructured 3D-printed biomaterials designed for personalised, cell-free healing and enhanced regeneration of aged and diseased bone. These biomaterials combine architectural precision, bioactive ion modulation, and anti-senescence strategies to support robust bone repair in large and complex skeletal defects. Beyond materials innovation, this work contributes to a broader vision for biomedical engineering, one that unites materials science, computation, and medicine to achieve lifelong skeletal health. By integrating bioactive materials, mechanobiological insights, and data-driven design, we aim to accelerate translation from the laboratory to the clinic. The presentation will also reflect on how international collaboration, interdisciplinary training, and sustainable innovation can shape the next phase of musculoskeletal care and the future of biomedical engineering.